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. 2019 May 21;6:108. doi: 10.3389/fmed.2019.00108

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Copyright © 2019 Talagas and Misery.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identified exogenous stimuli and the corresponding keratinocyte sensory receptors triggering pain or itch in mouse models. (A) Chemical stimuli. Capsaicin can induce pain through the activation of keratinocyte-expressed TRPV1. By extension this process probably concerns H+ ions. (B) Chemical stimuli. Histamine and endothelin-1 activate TRPV4 through their respective receptors. Downstream TRPV4 activation induces itch. (C) Thermal stimuli. TRPV1 is also the main transducer of noxious heat. (D) Physical stimuli. UVB activate keratinocyte-expressed TRPV4 to induce pain. (E) Like intense pressure via not yet identified mechanoreceptor(s).