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. 2019 May 21;9:394. doi: 10.3389/fonc.2019.00394

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Copyright © 2019 Li, Bai, Feng, Li, Yang, Guo, Lin, Zhang, He, Hu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High percentage of hypermethylation of the HOXA2, HOXA5, and HOXA6 genes in colorectal cancer tissue. (A) A “Mutation Matrix” plot between genes and samples for colorectal tissue that contains the top 20 ranked genes (rows) and TCGA samples (columns) with each box representing a Gene-Sample combination. HOXA2, HOXA5, and HOXA6 ranked 1, 3, and 17, respectively (only some TCGA samples are listed here; more details can be found on the COSMIC website). (B) The hypermethylation percentages (% me) are represented as histograms across the different primary tissue types, and the percentage of hypermethylation of HOXA2, HOXA5, and HOXA6 in the large intestine rank first. Test: Total number of samples analyzed (only some cancer samples are listed here; more details can be found on the COSMIC website). (C–E) HOXA2, HOXA5, and HOXA6 genes show increased methylation levels in colorectal cancer tissues compared with normal tissues (Unpaired t-test, ^*all p < 0.0001).