Table 4.
The relationship between the methylation levels of HOXA2 and clinicopathological factors.
| Factor# | No. | HOXA2 | P | |
|---|---|---|---|---|
| Low, n (%) | High, n (%) | |||
| AGE | ||||
| < 60 | 136 | 64 (47.06) | 72 (52.94) | 0.009* |
| ≥60 | 252 | 84 (33.33) | 168 (66.67) | |
| GENDER | ||||
| Male | 210 | 75 (35.71) | 133 (64.29) | 0.296 |
| Female | 178 | 73 (41.01) | 105 (58.99) | |
| HEIGHT | ||||
| < 170 | 138 | 56 (40.58) | 82 (59.42) | 0.811 |
| ≥170 | 151 | 59 (39.07) | 92 (60.93) | |
| WEIGHT | ||||
| < 80 | 156 | 60 (38.46) | 96 (61.54) | 0.816 |
| ≥80 | 152 | 61 (40.13) | 91 (59.87) | |
| RACE | ||||
| Asian | 12 | 3 (25.00) | 9 (75.00) | 0.174 |
| Black | 62 | 19(30.65) | 43 (69.35) | |
| White | 280 | 116(41.43) | 164(58.57) | |
| T | ||||
| T1 | 11 | 3 (27.27) | 8 (72.73) | 0.187 |
| T2 | 54 | 15 (27.78) | 39 (72.22) | |
| T3 | 270 | 105 (38.89) | 165 (61.11) | |
| T4 | 51 | 24 (47.06) | 27 (52.94) | |
| N | ||||
| N0 | 212 | 67 (31.60) | 145 (68.40) | 0.002*a |
| N1 | 103 | 54 (52.43) | 49 (47.57) | |
| N2 | 70 | 25 (35.71) | 45 (64.29) | |
| M | ||||
| M0 | 264 | 89 (33.71) | 175 (66.29) | 0.005* |
| M1 | 53 | 29 (54.72) | 24 (45.28) | |
| STAGE | ||||
| I | 54 | 15 (27.78) | 39 (72.22) | 0.016*a |
| II | 143 | 47 (32.87) | 96 (67.13) | |
| III | 118 | 49 (41.53) | 69(58.47) | |
| IV | 54 | 29 (53.70) | 25 (46.30) | |
| LYMPHOVASCULAR INVASION | ||||
| Yes | 107 | 52 (48.60) | 55 (51.40) | 0.018* |
| No | 231 | 81 (35.06) | 150 (64.94) | |
| VASCULAR INVASION | ||||
| Yes | 78 | 33 (42.31) | 45 (57.69) | 0.508 |
| No | 254 | 96 (37.80) | 158 (62.20) | |
| PERINEURAL INVASION | ||||
| Yes | 59 | 34 (57.63) | 25 (42.37) | 0.005* |
| No | 170 | 62 (36.47) | 108 (63.53) | |
| KRAS Mutation | ||||
| Yes | 28 | 6 (21.43) | 22 (78.57) | 0.152 |
| No | 28 | 12 (42.86) | 16 (57.14) | |
| LYMPH NODES NO.HE | ||||
| 0 | 192 | 63 (32.81) | 129 (67.19) | 0.005*a |
| 1–3 | 95 | 50 (52.63) | 45 (47.37) | |
| ≥4 | 67 | 25(37.31) | 42 (62.69) | |
| LYMPH NODES NO | ||||
| < 18 | 168 | 60 (35.71) | 108 (64.29) | 0.327 |
| ≥18 | 189 | 78 (41.27) | 111 (58.73) | |
| TUMOR STATUS | ||||
| Tumor free | 246 | 97 (39.43) | 149 (60.57) | 0.794 |
| With tumor | 82 | 31 (37.80) | 51 (62.20) | |
| TUMOR SIZE | ||||
| < 0.5 | 123 | 42 (34.15) | 81 (65.85) | 0.059 |
| ≥0.5 | 108 | 50 (46.30) | 58 (53.70) | |
| SURGICAL MARGIN | ||||
| R0 | 256 | 100 (39.06) | 156 (60.94) | 0.423 |
| R1 | 5 | 1 (20.00) | 4 (80.00) | |
| R2 | 7 | 4 (57.14) | 3 (42.86) | |
| HISTORY | ||||
| Yes | 31 | 10 (32.26) | 21 (67.74) | 0.566 |
| No | 357 | 138 (38.66) | 219 (61.34) | |
| TUMOR SITE | ||||
| Ascending colon | 55 | 17 (30.91) | 38 (69.09) | 0.003*a |
| Cecum | 74 | 22 (29.73) | 52 (70.27) | |
| Descending colon | 14 | 6 (42.86) | 8 (57.14) | |
| Rectosigmoid junction | 46 | 26 (56.52) | 20 (43.48) | |
| Transverse colon | 47 | 15(31.91) | 32(68.09) | |
| Rectum | 45 | 10 (22.22) | 35 (77.78) | |
| Sigmoid colon | 88 | 43 (48.86) | 45 (51.14) | |
*
Means the result has statistical significance, # more details about explanation for Factor can be found in the TCGA database.
a
If multiple hypotheses are tested, the Bonferroni correction was used to adjust the significance level for each individual test to a stricter one, the Bonferroni correction test each individual hypothesis at a significance level of 0.05/m. m is the number of hypotheses.