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. 2019 May 24;21(7):702–712. doi: 10.1016/j.neo.2019.05.002

Figure 2.

Figure 2

Increased Notch pathway component expression in human gastric adenocarcinoma. (A-E) Normalized RNAseq data from The Cancer Genome Atlas (TCGA) database examining 35 normal stomach and 415 gastric adenocarcinoma tissue samples. Gene expression analysis of (A) Notch receptors, (B&C) Notch ligands and (D&E) Notch target genes in normal (white circles) and gastric adenocarcinoma (black circles) samples. Analysis of the 4 molecular subtypes of gastric adenocarcinomas is presented in Supplementary Figure 1. (F&G) RT-qPCR analysis of Notch receptors (F) and Notch ligands (G) in paired non-cancer (white circles) and gastric cancer (gray circles) full-thickness tissue obtained from Michigan Medicine patients. See Supplementary Table 1 for information related to patient samples. Data are presented as mean ± SEM. *P < .05, **P < .01, ****P < .0001 vs. normal or non-cancer.