Figure 1.

(A) Effects of H₂O₂ and doxycycline on KCl (80 mM)-induced contractions in HSV rings. **p≤0.01 Control vs H₂O₂; ⁺p≤0.05 H₂O₂ vs H₂O₂ + Dox.; (n=5); Friedman test followed by Wilcoxon signed rank test. (B) Effects of H₂O₂ and doxycycline on cumulative NA (10⁻⁹–10⁻⁴ M)-induced contractions in HSV rings. *p≤0.05 Control vs H₂O₂; ⁺p≤0.05 H₂O₂ vs H₂O₂ + Dox.; (n=5); Friedman test followed by Wilcoxon signed rank test. (C) Effects of H₂O₂ and doxycycline on cumulative 5-HT (10⁻⁹–3x10^-5 M)-induced contractions in HSV rings. **p≤0.01 Control vs H₂O₂; (n=5); Friedman test followed by Wilcoxon signed rank test. All data are expressed as median and range (min-max).

Abbreviations: C, control; Dox., doxycycline.