Table 2.
Correlation of CD133 and CD24 expression with clinicopathological parameters
| Variables | CD133 | p-value1 | p-value2 | CD24 | P-value1 | P-value2 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Positive | Negative | Positive | Negative | |||||||
| Low | High | Low | High | |||||||
| n=12 | n=10 | n=38 | n=7 | n=10 | n=43 | |||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||
| Age | ||||||||||
| ≤50 (n=5) | 1 (8.3) | 0 (0) | 4 (10.5) | 0.54 | 0.38 | 0 (0) | 0 (0) | 5 (11.6) | 1 | 0.17 |
| >50 (n=55) | 11 (91.7) | 10 (100) | 34 (89.5) | 7 (100) | 10 (100) | 38 (88.9) | ||||
| Gender | ||||||||||
| Male (n=48) | 10 (83.3) | 8 (80) | 30 (78.9) | 0.63 | 0.53 | 5 (71.4) | 7 (70) | 36 (83.7) | 0.68 | 0.212 |
| Female (n=12) | 2 (16.7) | 2 (20) | 8 (21.1) | 2 (28.6) | 3 (30) | 7 (16.3) | ||||
| Histological type | ||||||||||
| Urothelial carcinoma (n=40) | 11 (91.7) | 7 (70) | 32 (84.2) | 0.225 | 0.53 | 6 (85.7) | 7 (70) | 37 (86.4) | 0.44 | 0.29 |
| Non-urothelial carcinoma (n=10) | 1 (8.3) | 3 (30) | 6 (15.2) | 1(14.3) | 3 (30) | 6 (14) | ||||
| Associated schistosomiasis | ||||||||||
| Present (n=10) | 1 (8.3) | 3 (30) | 6 (15.2) | 0.225 | 0.53 | 2 (28.6) | 2 (20) | 6 (14) | 0.55 | 0.295 |
| Absent (n=50) | 11 (91.7) | 7 (70) | 32 (84.2) | 5 (71.4) | 8 (80) | 37 (86) | ||||
| Histological grade | ||||||||||
| Low (1& 2) (n=22) | 3 (25) | 1 (10) | 18 (47.4) | 0.36 | 0.022 | 0 (0) | 2 (20) | 20 (46.5) | 0.33 | 0.01 |
| High (3) (n=38) | 9 (75) | 9 (90) | 20 (52.6) | 7 (100) | 8 (80) | 23 (53.5) | ||||
| Muscle invasion | ||||||||||
| Non-muscle invasive (n=16) | 2 (16.7) | 0 (0) | 14 (36.8) | 0.28 | 0.017 | 0 (0) | 0 (0) | 16 (37.2) | 1 | 0.001 |
| Muscle invasive (n=44) | 10 (83.3) | 10 (100) | 24 (63.2) | 7 (100) | 10 (100) | 27 (62.8) | ||||
| Lymphovascular invasion | ||||||||||
| Present (n=6) | 1(8.3) | 3(30) | 2 (5.3) | 0.225 | 0.12 | 2 (28.6) | 2 (20) | 2 (4.7) | 0.558 | 0.048 |
| Absent (n=54) | 11 (91.7) | 7 (70) | 36 (94.7) | 5 (71.4) | 8 (80) | 41 (95.3) | ||||
| Perineural invasion | ||||||||||
| Present (n=4) | 1 (8.3) | 0 (0) | 3 (7.9) | 0.54 | 0.53 | 1(14.3) | 0 (0) | 3 (7) | 0.41 | 0.68 |
| Absent (n=56) | 11 (91.7) | 10 (100) | 35 (92.1) | 6 (85.7) | 10(100) | 40 (93) | ||||
| Pathological stage | ||||||||||
| I (n=16) | 2 (16.7) | 0 (0) | 14 (36.8) | 1 | 0.0001 | 0 (0) | 0 (0) | 16 (37.2) | 0.79 | 0.007 |
| II (n=21) | 2 (16.7) | 3 (30) | 16 (42.1) | 4 (57.1) | 4 (40) | 13 (30.2) | ||||
| III (n=15) | 6 (50) | 5 (50) | 4 (10.5) | 2 (28.6) | 5 (50) | 8 (18.6) | ||||
| IV (n=8) | 2 (16.7) | 2 (20) | 4 (10.5) | 1(14.3) | 1 (10) | 6 (13.9) | ||||
| Lymph node metastasis | ||||||||||
| Present (n=7) | 1 (8.3) | 4 (40) | 2 (5.3) | 0.105 | 0.055 | 1(14.3) | 3(30) | 3 (7) | 0.44 | 0.09 |
| Absent (n=53) | 11 (91.7) | 6 (60) | 36 (94.7) | 6 (85.7) | 7(70) | 40 (93) | ||||
| Distant metastasis | ||||||||||
| Present (n=5) | 1 (8.3) | 4 (40) | 0 (0) | 0.105 | 0.0048 | 1(14.3) | 2(20) | 2 (4.7) | 0.639 | 0.132 |
| Absent (n=55) | 11(91.7) | 6 (60) | 38 (100) | 6 (85.7) | 8(80) | 41(95.3) | ||||
Notes: P-Value1: difference between high and low expression. P-Value2: difference between positive and negative expression. Statistically significant p-values are in bold.