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. 2019 May 23;11:4707–4718. doi: 10.2147/CMAR.S199329

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© 2019 Zhang et al.

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α2δ1 is more specific than CD44 in identifying gastric cancer stem cells. (A) Coexpression analysis of α2δ1 and CD44 in gastric cancer cell lines by flow cytometry. α2δ1⁺ cells account for a fraction of CD44⁺ cells. (B) Coexpression analysis of α2δ1 and CD44 in HGC-27 and MKN-45 cell lines by confocal microscope. (C) Comparison of sphere-formation frequency of purified α2δ1⁺CD44⁺ and α2δ1⁻CD44⁺ HGC-27 cells in vitro. α2δ1⁺CD44⁺ cells displayed significantly higher sphere-forming capacity compared with their α2δ1⁻CD44⁺ counterparts. *p<0.05.

Abbreviations: FITC, fluorescein isothiocyanate; APC, allophycocyanin.