Table 4.
α2δ1+ HGC-27 and α2δ1+ SGC-7901 cells possess highly tumorigenic capacity
| Group | Tumor formation (tumor formed/mice injected) | Frequency of tumorigenic cells | (95% CI) | p-Value | |
|---|---|---|---|---|---|
| Cells inoculated | |||||
| 102 | 103 | ||||
| α2δ1+HGC-27(A) | 5/8 | 7/8 | 1/271 | (1/639–1/115) | 0.0006 (A vs B) |
| α2δ1−HGC-27(B) | 2/8 | 2/8 | 1/1,903 | (1/5,342–1/678) | |
| α2δ1+SGC-7901(C) | 3/8 | 6/9 | 1/657 | (1/1,382–1/312) | 0.0177 (C vs D) |
| α2δ1−SGC-7901(D) | 1/8 | 2/9 | 1/2897 | (1/9,210–1/912) | |
Notes: The tumorigenic frequency and the comparison of the frequencies between different groups was calculated based on extreme limiting dilution analysis using the web tool at http://bioinf.wehi.edu.au/software/elda/(Hu and Smyth, 2009).36 p-value <0.05 was considered statistically significant.