Table 5.
The tumorigenic capacity of α2δ1+ HGC-27 cells are inhibited after α2δ1 knockdown
| Group | Tumor formation (tumor formed/mice injected) | Frequency of tumorigenic cells | (95% CI) | p-Value |
|---|---|---|---|---|
| α2δ1+HGC-27 | 8/8 | 1/1 | (1/86–1/1) | 0.0023 |
| Shα2δ1HGC-27 | 3/8 | 1/213 | (1/667–1/67.9) |
Notes: The tumorigenic frequency and the comparison of the frequencies between different groups was calculated based on extreme limiting dilution analysis using the web tool at http://bioinf.wehi.edu.au/software/elda/ (Hu and Smyth, 2009).36 p-value <0.05 was considered statistically significant.