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. 2019 May 21;24:101223. doi: 10.1016/j.redox.2019.101223

Table 1.

Chemical structures of taurine analogs, their major effects and their ability to cross the BBB.

Derivatives Ability to cross BBB Effects Investigated in
Image 2 +
  • ⁃

    Affects emotional arousal

  • ⁃

    Exhibits synergistic effects with anxiolytic drugs

 [159]
Image 3 +
  • ⁃

    Activates GABAA-R and enhances CD8+ and CD4+ Treg cell responses

  • ⁃

    Limits Th17- and Th1-mediated inflammation in the CNS

 [160]
Image 4 +
  • ⁃

    Increases striatal dopamine concentration

 [161]
Image 5 +
  • ⁃

    Modulates cerebral circulation in ischemic mice

 [141]
Image 6 – – –
Image 7 – – –
Image 8 +
  • ⁃

    Increases GABA content

 [145]
Image 9 – – –
Image 10 +
  • ⁃

    Restores NMDA receptor tone in the glutamate system

 [162]
Image 11 –
  • ⁃

    Stimulates ATP-dependent Ca2+ uptake and protects the retina

 [163]
Image 12 –
  • ⁃

    Stimulates ATP-dependent Ca2+ uptake and protects the retina

 [163]
Image 13 –
  • ⁃

    Stimulates ATP-dependent Ca2+ uptake and protects the retina

 [163]
Image 14 – – –
Image 15 – – –
Image 16 +
  • ⁃

    Acts on the depolarization-stimulated release of GABA

 [164]
Image 17 + ? [165]
Image 18 +
  • ⁃

    Inhibits ChE and MAO-B activities

 [166]
Image 19 – – –
Image 20 +
  • ⁃

    Possesses anticonvulsant properties

 [154]

+: Does cross; -: Does not cross; ?: Unknown.