Figure 6.

Tumor growth attenuation with MB+US-mediated delivery of siESE-1_1.3 directly into the tumor. BT-474-Luc xenograft tumor growth was evaluated in NOD/SCID female mice after siRNA direct injection into the tumors followed by MB+US delivery into tumor cells (*, p < 0.05). BT-474-Luc cells seeded in Matrigel plugs were injected into mammary fat pads, and tumor growth was measured as tumors became palpable. Initial tumor volume was recorded, and it ranged from 33.5-1230.9 mm³ (with initial tumor size having a median size of 131.9 mm³ and a mean size of 226.7 mm³). Final tumor volume was recorded two weeks after initial tumor volume and the data are presented as fold-increase of final volume over initial volume. The data in this figure is derived from six distinct injection studies (ie, six biological replicates, representing 50 mice and 59 tumors), and is represented over time (A) and after two weeks (B).