Table 4. Diagnostic Performance of FF, R2*, and Combination of FF and R2* for Predicting Osteopenia and Osteoporosis.
| Parameters | Normal vs. Osteopenia | Normal vs. Osteoporosis | ||||
|---|---|---|---|---|---|---|
| FF | R2* | FF + R2* | FF | R2* | FF + R2* | |
| Reader 1 | ||||||
| AUC | 0.651 (0.561–0.727) | 0.664 (0.568–0.734) | 0.716 (0.636–0.793) | 0.694 (0.609–0.776) | 0.743 (0.653–0.819) | 0.758 (0.669–0.832) |
| Sensitivity (%) | 97.3 (85.8–99.9) | 40.5 (24.8–57.9) | 59.5 (42.1–75.2) | 47.1 (23.0–77.0) | 64.7 (38.3–85.8) | 64.7 (38.3–85.8) |
| Specificity (%) | 36.4 (26.9–46.6) | 84.8 (76.2–91.3) | 79.8 (70.5–87.2) | 93.9 (87.3–97.7) | 83.8 (75.1–90.5) | 85.9 (77.4–92.0) |
| Cutoff value | > 49.6 | ≤ 14.9 | > 62.5 | ≤ 15.0 | ||
| †p value | 0.002 | 0.002 | < 0.001 | 0.028 | 0.001 | 0.003 |
| Reader 2 | ||||||
| AUC | 0.647 (0.561–0.727) | 0.654 (0.568–0.734) | 0.720 (0.636–0.793) | 0.741 (0.652–0.818) | 0.736 (0.646–0.813) | 0.763 (0.675–0.837) |
| Sensitivity (%) | 89.2 (74.6–97.0) | 45.9 (29.5–63.1) | 56.8 (39.5–72.9) | 58.8 (32.9–81.6) | 70.6 (44.0–89.7) | 70.6 (44.0–89.7) |
| Specificity (%) | 41.4 (31.6–51.8) | 79.8 (70.5–87.2) | 77.8 (68.3–85.5) | 90.9 (83.4–95.8) | 67.7 (57.5–76.7) | 81.8 (72.8–88.9) |
| Cutoff value | 50.8 | ≤ 14.9 | > 61.1 | ≤ 15.5 | ||
| †p value | 0.003 | 0.003 | < 0.001 | 0.002 | 0.001 | < 0.001 |
Numbers in parentheses are lower and upper bounds of 95% CIs. †p value of AUC. AUC = area under curve, CI = confidence interval