Table 5. Diagnostic Performance of FF, R2*, and Combination of FF and R2* for Predicting Osteopenia in Each Group.
| Parameters | Males (Age ≥ 50 Years) | Females (Postmenopausal) | ||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | AUC | P† | Sensitivity (%) | Specificity (%) | AUC | P† | |
| FF | ||||||||
| Reader 1 | 100.0 | 52.3 | 0.779 (0.651–0.877) | 0.001 | 96.8 | 25.0 | 0.604 (0.477–0.721) | 0.135 |
| Reader 2 | 100.0 | 46.2 | 0.768 (0.638–0.868) | 0.005 | 96.8 | 27.8 | 0.620 (0.493–0.736) | 0.083 |
| R2* | ||||||||
| Reader 1 | 100.0 | 26.9 | 0.518 (0.383–0.651) | 0.897 | 74.2 | 61.1 | 0.699 (0.575–0.805) | 0.003 |
| Reader 2 | 100.0 | 32.8 | 0.526 (0.390–0.658) | 0.856 | 74.2 | 72.2 | 0.735 (0.613–0.835) | < 0.001 |
| FF + R2* | ||||||||
| Reader 1 | 100.0 | 59.6 | 0.782 (0.654–0.880) | < 0.001 | 67.7 | 72.2 | 0.702 (0.577–0.807) | 0.002 |
| Reader 2 | 100.0 | 46.2 | 0.766 (0.636–0.867) | 0.005 | 77.4 | 66.7 | 0.736 (0.614–0.836) | < 0.001 |
Younger males and premenopausal females included only one osteopenic subject, resulting in insufficient data for ROC curve analysis. Numbers in parentheses are lower and upper bounds of 95% CIs. †p value of AUC. ROC = receiver operating characteristic