Skip to main content
. 2019 Apr 30;142(6):1503–1527. doi: 10.1093/brain/awz099

Figure 5.

Figure 5

Biomarkers are currently not specific to LATE-NC. (A) Radiological scans from an 86-year-old female who suffered amnestic cognitive impairment compatible with ‘Probable Alzheimer’s disease’ diagnosis. However, the amyloid-β PET scan was negative, tau PET scan was also negative, and the MRI showed appreciable atrophy of the medial temporal lobes bilaterally. This combination is considered ‘A−T−N+’ and was diagnosed during life as ‘suspected non-Alzheimer’s pathology’ (SNAP). Autopsy within a year of the brain scans confirmed the presence of TDP-43 pathology and hippocampal sclerosis, which now is diagnosable as LATE-NC. (B) Another common biomarker combination, in the brain of a 91-year-old male with dementia. In this subject, the amyloid PET scan was positive, yet the tau PET scan was negative. The MRI again showed atrophy of the medial temporal lobes. The combination of pathologies—in this case presumed early ADNC and comorbid LATE-NC—is common, especially in the brains of subjects in advanced age.