Table 3.

Grades of toxicity of increased serum creatinine after each cisplatin cycle and comparison between arms

Cycle/grades	Placebo arm (%)	NAC arm (%)	P value
First cycle	n = 29	n = 28	0.6484(‡)(a)
0	55.2	42.9
1	20.7	35.7
2	13.8	10.7
3	10.3	10.7
4	0.0	0.0
Second cycle	n = 18	n = 23	0.9507(†)(b)
0	55.6	56.5
1	33.3	26.1
2	0.0	8.7
3	11.1	8.7
4	0.0	0.0
Third cycle	n = 14	n = 16	1.0000(‡)(b)
0	85.7	81.3
1	14.3	6.2
2	0.0	12.5
3	0.0	0.0
4	0.0	0.0

^(†) Chi‐square test. ^(‡) Fisher's exact test. ^(a) Grade 0 vs grades 1 + 2 vs grades 3 + 4. ^(b) Grade 0 vs grades 1 + 2 + 3 + 4. n: absolute number of patients, NAC: acetylcysteine.