Table 4.

Univariate analysis on OS and PFS

Variable	OS			PFS
	HR	95% CI	Cox P‐value	HR	95% CI	Cox P‐value
Cytopenias: 2‐3	1.66	[1.04‐2.63]	0.032	1.64	[1.03‐2.60]	0.036
Transfusion dependence	1.78	[1.12‐2.82]	0.014	1.68	[1.06‐2.65]	0.027
AML with 21%‐30% blasts in the bone marrow	2.01	[1.22‐3.31]	0.006	1.83	[1.11‐3.00]	0.017
Poor karyotype (IPSS score)	2.73	[1.49‐4.99]	0.001	2.92	[1.62‐5.26]	<0.001
Poor and very poor karyotype (IPSS‐R score)	2.86	[1.60‐5.09]	<0.001	2.87	[1.66‐4.94]	<0.001
High IPSS score	2.62	[1.83‐3.76]	<0.001	2.47	[1.71‐3.58]	<0.001
<80% RDI (time‐dependent)	0.732	[0.44‐1.16]	0.182	1.02	[0.69‐1.51]	0.911

AML, acute myeloid leukemia; OS, Overall survivals; PFS, progression‐free survivals; RDI, relative dose intensity.