Table 1.
Characteristics of the whole cohort and by report of severe fatigue at 2 years after diagnosis
| Characteristics | Whole cohort N (%) | No severe fatigue N (%) | Severe fatigue N *(%) | Adjusted OR, (95%CI) | |
|---|---|---|---|---|---|
| Overall | 1984 (100) | 962 (48.5) | 1022 (51.5) | — | |
| PA before Dx | |||||
| Active | 1740 (87.7) | 849 (48.8) | 891 (51.2) | 1 | |
| Inactive | 231 (11.6) | 102 (44.2) | 129 (55.8) | 0.92 (0.66‐1.27) | |
| Missing | 13 (0.7) | 11 (84.6) | 2 (15.4) | — | |
| Change in PA since Dx | |||||
| Increased/maintained PA | 911 (45.9) | 557 (61.1) | 354 (38.9) | 1 | |
| Decreased PA/remained inactive | 1058 (53.3) | 393 (37.2) | 665 (62.9) | 2.32 (1.85‐2.90)* | |
| Missing | 15 (0.8) | 12 (80.0) | 3 (20.0) | — | |
| Tumor site | |||||
| Breast | 1213 (61.1) | 452 (37.3) | 761 (62.7) | 1 | |
| Prostate | 426 (21.5) | 312 (73.2) | 114 (26.8) | 0.997 (0.51‐1.95) | |
| Colorectal | 345 (17.4) | 198 (57.4) | 147 (42.6) | 1.17 (0.73‐1.87) | |
| Gender | |||||
| Female | 1374 (69.3) | 531 (38.7) | 843 (61.4) | 1 | |
| Male | 610 (30.8) | 431 (70.7) | 179 (29.3) | 0.63 (0.38‐1.04) | |
| Age at diagnosis | |||||
| Median (IQR) | 52 (45‐65) | 60 (48‐68) | 49 (44‐60) | 0.97 (0.95‐0.98)* | |
| Marital status | |||||
| In couple | 16 01 (80.7) | 783 (48.9) | 818 (51.1) | 1 | |
| Not in a couple | 365 (18.4) | 165 (45.2) | 200 (54.8) | 0.93 (0.70‐1.23) | |
| Missing | 18 (0.9) | 14 (77.8) | 4 (22.2) | — | |
| Education | |||||
| High school diploma or higher | 1390 (70.1) | 653 (47.0) | 737 (53.0) | 1 | |
| Less than high school | 588 (29.6) | 306 (52.0) | 282 (48.0) | 1.07 (0.82‐1.38) | |
| 6 (0.3) | 3 (50.0) | 3 (50.0) | — | ||
| Employment | |||||
| Employed/formation | 887 (44.7) | 369 (41.6) | 518 (58.4) | 1 | |
| Unemployed | 298 (15.0) | 90 (30.2) | 208 (69.8) | 1.01 (0.72‐1.40) | |
| Retired/unable to work | 790 (39.8) | 494 (62.5) | 296 (37.5) | 0.95 (0.64‐1.41) | |
| 9 (0.45) | 9 (100.0) | 0 (0) | — | ||
| Comorbidities | |||||
| No | 1059 (53.4) | 559 (52.8) | 500 (47.2) | 1 | |
| Yes | 925 (46.6) | 403 (43.6) | 522 (56.4) | 1.68 (1.34‐2.11)* | |
| Pain in the last 15 days before survey | |||||
| Never | 603 (30.4) | 459 (76.1) | 144 (23.9) | 1 | |
| Sometimes | 644 (32.5) | 326 (50.6) | 318 (49.4) | 2.14 (1.63‐2.80)* | |
| Often | 341 (17.2) | 91 (26.7) | 250 (73.3) | 5.37 (3.85‐7.51)* | |
| Very often | 255 (12.9) | 58 (22.8) | 197 (77.3) | 6.30 (4.30‐9.21)* | |
| Constantly | 139 (7.0) | 27 (19.4) | 112 (80.6) | 7.39 (4.47‐12.2)* | |
| Missing | 2 (0.1) | 1 (50.0) | 1 (50.0) | — | |
| BMI before Dx | |||||
| Underweight (<18.5) | 43 (2.2) | 13 (30.2) | 30 (69.8) | 1.42 (0.67‐3.01) | |
| Normal (18.5‐24.9) | 1056 (53.2) | 473 (44.8) | 583 (55.2) | 1 | |
| Overweight (25.0‐29.9) | 630 (31.8) | 359 (57.0) | 271 (43.0) | 0.80 (0.62‐1.04) | |
| Obese≥30.0) | 243 (12.3) | 115 (47.3) | 128 (52.7) | 0.90 (0.64‐1.28) | |
| Missing | 12 (0.6) | 2 (16.7) | 10 (83.3) | — | |
| BMI variation since Dx | |||||
| >‐10% and <+10% | 1652 (83.3) | 868 (52.5) | 784 (47.5) | 1 | |
| ≤‐10.0% | 78 (3.9) | 23 (29.5) | 55 (70.5) | 2.01 (1.14‐3.55)** | |
| ≥+10.0% | 238 (12.0) | 68 (28.6) | 170 (71.4) | 1.22 (0.86‐1.73) | |
| Missing | 16 (0.8) | 3 (18.8) | 13 (81.3) | — | |
| Alcohol consumption | |||||
| <4/week | 1559 (78.6) | 699 (44.8) | 860 (55.2) | 1 | |
| ≥4/week | 419 (21.1) | 257 (61.3) | 162 (38.7) | 0.99 (0.75‐1.33) | |
| Missing | 6 (0.3) | 6 (100.0) | 0 (0) | — | |
| Smoking | |||||
| No | 1623 (81.8) | 814 (50.2) | 809 (49.9) | 1 | |
| Yes | 356 (17.9) | 143 (40.2) | 213 (59.8) | 0.997 (0.75‐1.33) | |
| Missing | 5 (0.3) | 5 (100) | 0 (0) | — | |
| Surgery | |||||
| No | 169 (8.5) | 109 (64.5) | 60 (35.5) | 1 | |
| Yes | 1814 (91.4) | 852 (47.0) | 962 (53.0) | 0.63 (0.40‐1.002) | |
| Missing | 1 (0.1) | 1 (100) | 0 (0) | — | |
| Chemotherapy | |||||
| No | 1084 (54.6) | 628 (57.9) | 456 (42.1) | 1 | |
| Yes | 900 (45.4) | 334 (37.1) | 566 (62.9) | 1.22 (0.95‐1.56) | |
| Radiation therapy | |||||
| No | 708 (35.7) | 455 (64.3) | 253 (35.7) | 1 | |
| Yes | 1273 (64.2) | 506 (39.8) | 767 (60.3) | 1.38 (1.02‐1.88)*** | |
| Missing | 3 (0.2) | 1 (33.3) | 2 (66.7) | ||
| Endocrine therapy | |||||
| No | 1060 (53.4) | 607 (57.3) | 453 (42.7) | 1 | |
| Yes | 921 (46.4) | 353 (38.3) | 568 (61.7) | 1.13 (0.87‐1.48) | |
| Missing | 3 (0.2) | 2 (66.7) | 1 (33.3) | — | |
PA: physical activity; Dx: diagnosis
*P < 0.001; ** P = 0.016; *** P = 0.036