Table 1.
Top SNP P‐values from gene regions associated with EOC in African American OncoArray analysis
| SNP ID (Effect/other allele) Nearest gene(s) | Effect Allele Frequency | N | OR | 95% CI | P‐value | Bayesian False Discovery Probability (BFDP) | Imputation quality |
|---|---|---|---|---|---|---|---|
| rs10017134 (C/T) UGT2A1/2a, b | 0.73 | 1990 | 1.4 | 1.2‐1.7 | 1.2 × 10−6 | 0.020 | 0.998 |
| rs2288741 (T/G) UGT2A1/2b | 0.73 | 1990 | 1.4 | 1.2‐1.6 | 1.9 × 10−6 | — | — |
| rs11939884 (T/G) UGT2A1/2a, b | 0.14 | 1990 | 0.7 | 0.5‐0.8 | 1.7 × 10−6 | — | — |
a
Imputed.
b
Bonferroni correction was applied to adjust for multiple SNPs comparisons. There were 433 SNPs in UGT2A1/2 gene. BFDP is reported based on a prior probability of association (pi0) equal to 0.6 * 1/(Number of SNPs/3).