Table 2.
Top SNP P‐values from gene regions associated with HGSOC in African American OncoArray analysis
| SNP ID (Effect/other allele) Nearest gene(s) | Effect Allele Frequency | N | OR | 95% CI | P‐value | Bayesian False Discovery Probability (BFDP) | Imputation quality |
|---|---|---|---|---|---|---|---|
| rs114972508 (T/C) EGFRa, b | 0.04 | 1772 | 2.3 | 1.2‐3.4 | 1.6 × 10−5 | 0.293 | 0.890 |
| rs10017134 (C/T) UGT2A1/2a,b | 0.72 | 1772 | 1.4 | 1.2‐1.7 | 2.3 × 10−5 | 0.228 | 0.998 |
| rs2288741 (T/G) UGT2A1/2b | 0.72 | 1772 | 1.4 | 1.2‐1.7 | 3.1 × 10−5 | — | — |
a
Imputed.
b
Bonferroni correction was applied to adjust for multiple SNPs comparisons. There were 824 SNPs in EGFR gene, and 413 SNPs in UGT2A1/2 gene. BFDP is reported based on a prior probability of association (pi0) equal to 0.5 * 1/(Number of SNPs/3).