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Inhibitor of PHF5A inhibited lung adenocarcinoma (LUAD) cell proliferation and induced similar alternative splicing (AS) events. A, The IC50 curve of pladienolide in H1299 and A549 cell lines. B and C, CCK8 assays in H1299 (B) and A549 (C) cell lines treated with different concentrations of pladienolide. D and E, Validation of AS events in partial genes in H1299 (D) and A549 (E) cell lines treated with different concentrations of pladienolide. ****P < 0.0001
