Table 3A.

Differences in medication adherence, beliefs about medication, and clinical outcome between usual care and intervention groups at baseline, after intervention and at follow-up of 12 months (all after imputation)

	Group I+II Usual care (UC) N=271	Group II UC+consultations N=148	p-valuea
Mean possesion ratiob
Total of cardiovascular medication
Baseline (T1)	0.74	0.73
After intervention (T2)	0.93	0.89	0.08
Follow up of 12 months (T3)	0.81	0.76	0.23
Per ATC-code
Baseline (T1)
Antithrombotic agents (B01)	0.77	0.73
Diuretics (C03)	0.79	0.73
Beta blocking agents (C07)	0.87	0.83
Calcium channel blockers (C08)	0.95	0.94
Agents acting angiotensin (C09)	0.80	0.79
Lipid modifying agents (C10)	0.80	0.76
After intervention (T2)
Antithrombotic agents (B01)	0.92	0.91	0.65
Diuretics (C03)	0.88	0.82	0.40
Beta blocking agents (C07)	0.91	0.91	0.89
Calcium channel blockers (C08)	0.89	0.87	0.57
Agents acting angiotensin (C09)	0.92	0.91	0.56
Lipid modifying agents (C10)	0.90	0.89	0.06
Follow up of 12 months (T3)
Antithrombotic agents (B01)	0.86	0.82	0.27
Diuretics (C03)	0.83	0.76	0.12
Beta blocking agents (C07)	0.80	0.80	0.87
Calcium channel blockers (C08)	0.93	0.91	0.34
Agents acting angiotensin (C09)	0.84	0.80	0.48
Lipid modifying agents (C10)	0.84	0.78	0.06
Adherentc
Baseline (T1)	53.5	48
After intervention (T2)	86.3	76.4	0.17
Follow up of 12 months (T3)	64.9	76.4	0.38
Modified Morisky Scaled
Baseline (T1)
Low	19.6	21.6
Medium	46.5	41.2
High	32.7	37.2
After intervention (T2)
Low	28.7	31	0.94e
Medium	38	38.5
High	33.3	30.5
Beliefs about medication questionnaire
Necessity concern differentialf
Baseline (T1)	3.7	3.4
After intervention (T2)	3.8	3.9	0.86
Categoriesg
Baseline (T1)
Accepting	27.3	25
Ambivalent	62.7	60.1
Sceptical	4.4	5.4
Indifferent	5.5	9.5
After intervention (T2)
Accepting	26.6	32.8
Ambivalent	43.2	37.1
Sceptical	14.8	17.6
Indifferent	15.2	12.6
Clinical outcomes
Systolic blood pressure (mmHg)
Baseline (T1)	136.4	136.7
After intervention (T2)	155	155	0.71
Adherenth	25	20.9	0.52
Low- density cholestrol (mmol/L)
Baseline (T1)	2.5	2.5
After intervention (T2)	2.2	2.2	0.74
Adherenti	90.4	86.4	0.4

Notes: ^aUsual care and usual care + are combined and compared with usual care ++ group. ^bMean number of days dispended divided by the mean number of days between prescription refill. ^cPercentage of patients (%) considered adherent according to PRD total of the cardiovascular medication (PRD was above or equal to 0.8). ^dPercentage of patients (%) who had low, medium, or high adherent scores. ^eLow and medium adherence are combined and compared with high adherence group. ^fDifferences between concern and necessity scores (means). ^gPercentage of patients (%) who are classified in the four different categories of the BMQ. ^hPercentage of patients (%) considered adherent according to systolic blood pressure (<135 mmHg) and percentage (%) of patients using antihypertension drugs. ⁱPercentage of patients (%) considered adherent according to LDL level (the recorded LDL level after intervention was 20% lower of baseline LDL cholesterol).