Figure 4.

MMP20 interacts with DSPP in the normal and cancer breast, colon, prostate, cervix and thyroid tissue microarrays. Micrographs showing DSPP interaction with MMP‐20 assessed by in situ proximity ligation assay (PLA) in normal and invasive ductal carcinoma of breast tissue (a‐d); normal and adenoma colon tissue (e‐h); normal and hyperplasia prostate tissue (i‐l); normal and squamous cell carcinoma of cervix tissue (m‐p); and, normal and papillary carcinoma of thyroid tissue (q‐t); preimmune IgG negative control (u); normal oral mucosa (tissue) negative control (v); oral squamous cell carcinoma (OSCC) positive control (w). PLA signals (brown dots) were detected using bright field microscopy (20×). Scale bar, 100 μm