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. 2019 May 17;7:2050313X19850435. doi: 10.1177/2050313X19850435

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — The one-carbon cycle (1-CC) and the folic acid (FA) cycle: The poor capacity to metabolize high doses of FA by the liver (6) induces an accumulation of homocysteine and unmetabolized FA and may induce a reversal of the 1-CC.

SAM: S-adenosyl methionine; SAH: S-adenosyl homocysteine; DHFR: dihydrofolate reductase; MTHFR, methylenetetrahydrofolate reductase; THF: tetrahydrofolate; MTHF: methyltetrahydrofolate.