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. 2019 May 20;15:1744806919842473. doi: 10.1177/1744806919842473

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Pharmacological blocking of ET_AR, PKA, and TRPA1 attenuates ET-1-induced mechanical hyperalgesia in mice. PWT of mice was measured by von Frey hair test. BQ-123 (1 µg/paw), H89 (5 µg/paw), or HC-030031 (10 µg/paw) was coinjected with ET-1 (20 ng/paw) into the hind paw of mice. Control group received vehicle (1% DMSO in PBS) injection only. PWT was measured before injection (baseline) and 0.5, 2.5 h after the injection. n = 7 mice/group. **p < 0.01 versus control group, ^##p < 0.01, ^#p < 0.05 versus ET-1+Veh group.

ET-1: endothelin-1; PWT: paw withdraw threshold.