Table 1.

Effect of intraplantar injection of BQ-123, H89, or HC-030031 on the PWTs of mice.

Group	PWT (g)
	0 h	0.5 h	2.5 h
Control	2.7 ± 0.4	2.0 ± 0.4	2.5 ± 0.5
+BQ-123	2.3 ± 0.3 (NS)	2.1 ± 0.4 (NS)	2.1 ± 0.4 (NS)
+H89	2.7 ± 0.4 (NS)	2.0 ± 0.4 (NS)	2.2 ± 0.4 (NS)
+HC-030031	2. 7± 0.4 (NS)	2.2 ± 0.4 (NS)	2.6 ± 0.5 (NS)

PWT: paw withdrawal threshold; NS: no significance.

BQ-123 (1 µg/paw), H89 (5 µg/paw), or HC-030031 (10 µg/paw) and corresponding vehicle (1% dimethyl sulfoxide in phosphate-buffered saline, control) were administered intraplantarly into the hind paws of mice. PWTs were measured before and 0.5 and 2.5 h after drug/vehicle treatment.