Table 2.

Global RNFL thickness change between baseline, week 12, and week 24.

		Affected eye		Unaffected eye
		Placebo	LA	Placebo	LA
Cross-sectional RNFL (µm) (mean ± SD) (95% CI)	Baseline	103.67 ± 18.04	108.47 ± 26.11	96.93 ± 11.90	96.40 ± 8.30
		(94.54, 112.80)	(95.25, 121.68)	(90.91, 102.95)	(92.20, 100.60)
	12 Weeks	89.43 ± 17.10	90.91 ± 23.02	96.00 ± 15.21	96.27 ± 8.83
		(80.47, 98.39)	(77.31, 104.51)	(88.03, 103.97)	(91.05, 101.49)
	24 Weeks	84.43 ± 20.94	79.31 ± 19.26	94.57 ± 16.37	96.85 ± 9.30
		(73.46, 95.40)	(68.84, 89.78)	(85.99, 103.15)	(91.79, 101.90)
Longitudinal change (µm) (mean ± SD) (95% CI)	12 Week change (BL to W12)	–13.77 ± 15.43	–13.64 ± 29.20	1.00 ± 3.03	0.73 ± 3.44
		(–22.16, –5.38)	(–30.89, 3.62)	(–0.65, 2.65)	(–1.30, 2.76)
	12 Week change (W12 to W24)	–5.00 ± 6.06	–8.60 ± 10.78	–1.43 ± 4.40	–0.50 ± 1.27
		(–8.18, –1.82)	(–15.28, –1.92)	(–3.73, 0.88)	(–1.29, 0.29)
	24 Week change (BL to W24)	–18.77 ± 18.88	–31.31 ± 38.30	0.00 ± 2.12	0.15 ± 2.48
		(–29.03, –8.50)	(–52.13, –10.49)	(–1.15, 1.15)	(–1.19, 1.50)

RNFL: retinal nerve fiber layer; LA: lipoic acid; SD: standard deviation; CI: confidence interval; BL: baseline.