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. 2019 May 17;18:1536012119848927. doi: 10.1177/1536012119848927

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — mAChR expression is decreased in A1 and rostral belt (RB)following noise exposure. Autoradiographic images showing [³H]scopolamine binding in representative coronal sections through RB (A) and A1 (B) on left (noise exposed) and right hemispheres. Panel C shows a high magnification view of A1 (of panel B) with standardized areas of analysis drawn over the 3 cortical subregions: supragranular (1), granular (2), and infragranular (3) with Giemsa counterstained image to verify layers. Quantified optical density measures for [³H]scopolamine binding are shown in the bar graphs for both the RB (D) and A1 (E) comparing left (L) and right (R) cortical hemispheres between both groups (noise: black; sham: white). Significant differences between noise and sham controls were noted in the right hemisphere (contralateral to noise exposure) versus left (* P < .05; standard deviation). Scale bars represent 1-mm increments. mAChR indicates muscarinic acetylcholine receptor.