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. Author manuscript; available in PMC: 2019 May 28.
Published in final edited form as: Science. 2018 Jun 7;361(6397):eaat0839. doi: 10.1126/science.aat0839

Figure 2. Overall architecture of TfuCascade/R-loop/Cas3 in the pre-nicking state.

Figure 2.

Cryo-EM map (A) and cartoon model (B) of the pre-nicking ternary complex in three different orientations, revealing the Cas3 protein binding to the Cse1 subunit of Cascade. The cryo-EM maps are displayed without applying B-factor sharpening.