Figure 1. Connectome analysis.

(A) Whole-brain structural connectomes in healthy controls, temporal lobe epilepsy patients with histologic confirmed hippocampal sclerosis (TLE-HS), and temporal lobe epilepsy patients with isolated gliosis (TLE-G). Connectomes were generated using systematic diffusion tractography between all regions, parcellated according to automated anatomical labeling. Letters in the matrix refer to regional groupings of the nodes (i.e., F = frontal, L = limbic, O = occipital, P = parietal, S = subcortical, T = temporal). (B) Graph theoretical topological measures of clustering coefficient and path length highlighting marked alterations in patients with TLE-HS, while those with TLE-G are only moderately affected compared to controls.