Figure 1. Timelines (in days) of anti–leucine-rich glioma-inactivated 1 encephalitis patients with epileptic seizures.

The percentages shown on the left correspond to patients (1) reaching seizure freedom after the use of immunotherapy (green), (2) reaching seizure freedom probably after the use of immunotherapy (triple green), (3) reaching seizure freedom after the use of antiepileptic drugs (AEDs) (red), (4) reaching seizure freedom probably after the use of AEDs (double red), (5) who could not be categorized (gray stripes), and (6) who did not reach seizure freedom (black dots). If patients were treated with another immunomodulating treatment >1 month after the initial treatment (for example, IV immunoglobulin after prednisolone), this is shown as a new blue square. Treatment with an additional AED or dosage increase after >1 month is shown as a second purple diamond. Relapses are only shown if patients had seizures. Median time of follow-up from onset was 33 months (interquartile range [IQR] 19–52, range 8–119). Median time of seizure freedom was 23 months (IQR 14–40, range 4–102). The median interval between start of AEDs and start of immunotherapy was 57 days (IQR 27–152). **Timeline of the only patient who developed epilepsy after resolved encephalitis. The symbols in this timeline are not fitted to scale. The onset of seizures was in 2009, the patient was treated with prednisone (and AEDs), leading to reversibility of cognitive signs, but he still has temporal epilepsy. IT = immunotherapy.