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. 2019 May 28;38:223. doi: 10.1186/s13046-019-1210-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Elevated stromal adipocyte characteristics and metabolite biomarkers in breast cancer are linked to a poor prognosis. a Representative immunohistochemistry staining of UCP1, MCT4, MCT1, CD36, FABP4 and FATP1. The pictures show positive cytoplasmic staining for UCP1 and positive membrane staining for MCT4 and CD36 in stromal adipocytes from breast cancer specimens. The pictures also show positive staining for FATP1 and CD36 in breast cancer tissues located near stromal adipocytes. b Correlation analyses of protein expression levels among UCP1, MCT4, and MCT1. MCT4 versus UCP1 (up) and MCT1 (down). c Kaplan-Meier survival analysis of patients with biomarker-positive and biomarker-negative IHC staining, as well as analysis of the double-positive group versus the double-negative group