Table 3.
Univariate and Multivariate Associations of 1-Year Mortality by Childhood Cancer Diagnosis at Uganda Cancer Institute.
| Characteristics | Summary Statistics | Acute Lymphoblastic Lymphoma(N =
28) |
Summary Statistics | Wilms Tumor (N = 28) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||
| Age (years), median (range), per 1-year increase | 10 (5-14) | 1.05 (0.97-1.15) | .24 | 2.4 (1.5-3.5) | 1.12 (0.95-1.31) | .18 | ||||
| Females, n (%); vs males | 16 (57.1) | 0.77 (0.27-2.18) | .62 | 14 (50) | 1.09 (0.36-3.30) | .88 | ||||
| Histology, n (%) | 26 (98.3) | 26 (92.9) | ||||||||
| Fever, n(%); vs no fever | 26 (92.9) | 1.97 (0.26-14.93) | .51 | 19 (67.7) | 3.22 (0.71-14.57) | .13 | ||||
| Edema, n (%); vs no edema | 3 (10.7) | 3.45 (0.71-16.74) | .12 | 2 (7.1) | 0.75 (0.1-5.81) | .79 | ||||
| Under weight for age, n (%) | 7 (33.3) | 0.43 (0.15-1.28) | .13 | 7 (31.8) | 1.67 (0.4-6.93) | .48 | ||||
| HIV positive, n (%); vs HIV negative | 1 (3.6) | 0 (0) | ||||||||
| Hb, median (IQR), per 1 g increase | 6.5 (4.9-9.1) | 1.19 (0.97-1.47) | .09 | 1.47 (1.00-2.16) | .05 | 9.8 (7.6-11.5) | 0.87 (0.7-1.1) | .25 | ||
| Hb <8 g/dL, n (%); vs ≥8 g/dL | 17 (63) | 3.14 (1.02-9.67) | .05 | 7 (29) | 2.26 (0.72-7.14) | .17 | ||||
| Plt <150 × 103/dL, n (%); vs ≥150 × 103/dL | 18 (72.0) | 0.52 (0.20-1.38) | .19 | 2 (8.7) | 1.85 (0.23-15.23) | .57 | ||||
| Late stage, n (%); late vs earlya | 4 (14.3) | 1.21 (0.35-4.21) | .76 | 0.33 (0.05-2.07) | .24 | 15 (53.8) | 1.32 (0.17-10.23) | .78 | ||
Abbreviations: HR, hazard ratio; CI, confidence interval; HIV, Human immune deficiency virus; hb, hemoglobin level; IQR, interquartile range; Plt, platelet count.
a
Late-stage disease (stages III and IV); early stage (stages III and IV).