. 2019 May 13;7:2050312119849766. doi: 10.1177/2050312119849766

Table 1.

Effect of 80ME and its solvent fractions of the leaves of V. amygdalina on parasitemia suppression and survival time of infected mice.

Category	Treatment	Dose (mg/kg)	% parasitemia	% suppression	MST (days)
Crude	NC	−	50.00 ± 0.58	0.00	6.50 ± 0.22
	80ME	200	33.77 ± 1.33	32.47 ± 2.65^a^*,^b^*	9.50 ± 0.42^a^,^b^,^c^
	80ME	400	32.30 ± 1.57	35.40 ± 3.14^a^*,^b^*	10.17 ± 0.79^a^*,^b^*
	80ME	600	31.17 ± 1.25	37.67 ± 2.50^a^*,^b^*	12.00 ± 0.58^a^*,^b^*
	PC	25	0.00	100	29.67 ± 0.21
Solvent fractions	NC	−	47.13 ± 4.04	0.00	6.67 ± 0.33
	CF	100	36.88 ± 2.54	21.68 ± 5.41^a^,^b^**	8.5 ± 0.43^a^,^b^**
	CF	200	35.90 ± 0.89	23.72 ± 1.92^a^,^b^**	9.00 ± 0.58^a^,^b^*
	CF	400	31.15 ± 4.27	33.85 ± 9.08^a^*,^b^*	9.83 ± 0.40^a^*,^b^*
	PC	25	0.00	100	29.5 ± 0.34
	NC	−	49.81 ± 3.83	0.00	6.33 ± 0.49
	BF	100	41.60 ± 2.45	18.12 ± 4.82^a^*,^b^*	7.83 ± 0.31^a^,^b^**
	BF	200	39.33 ± 0.31	21.03 ± 0.62^a^*,^b^*	8.50 ± 0.0.23^a^,^b^**
	BF	400	36.55 ± 0.35	26.88 ± 0.70^a^*,^b^*	9.17 ± 0.31^a^*,^b^,^d^**
	PC	25	0.00	100	29.33 ± 0.33
	NC	−	57.78 ± 3.09	0.00	6.00 ± 0.26
	AF	100	56.42 ± 2.89	5.60 ± 3.60^b^***	6.00 ± 0.37^b^**,^c^
	AF	200	55.33 ± 0.83	6.72 ± 1.74^b^***	6.50 ± 0.22^b^***
	AF	400	52.55 ± 2.97	9.75 ± 4.84^b^***	7.33 ± 0.21^a^,^b^**
	PC	25	0.00	100	29.5 ± 0.34

Data are expressed as mean ± SEM; n = 6; NC = negative control (0.2 mL tween-80/distilled water); PC: positive control (chloroquine); AF: aqueous fraction; BF: butanol fraction; CF: chloroform fraction; MST: mean survival time.

Compared to negative control.

Compared to positive control.

Compared to 600 mg/kg (80ME) and 400 mg/kg (solvent fractions).

Compared to chloroform.

p < 0.05; **p < 0.01; ***p < 0.001.