. 2019 May 13;7:2050312119849766. doi: 10.1177/2050312119849766

Table 2.

Effect of 80ME and its solvent fractions on body temperature, body weight and PCV of P. berghei-infected mice.

Category	Treatment	Dose mg/kg)	Body Temperature (°C)			Body Weight (g)			Packed cell volume
Category	Treatment	Dose mg/kg)	D0	D4	% change	D0	D4	% change	D0	D4	% change
Crude	NC	–	36.3 ± 0.1	34.1 ± 0.2	−3.4 ± 0.1	24.2 ± 0.8	21.0 ± 0.4	−15.3 ± 2.8	76.9 ± 0.9	52.5 ± 1.18	−46.9 ± 4.2
	80ME	200	36.7 ± 0.2	34.8 ± 0.1	−2.1 ± 0.6^a^,^b^*,^d^	24.9 ± 1.2	26.2 ± 0.1	5.3 ± 0.6^a^***	75.3 ± 1.7	64.5 ± 1.24	−16.9 ± 3.2^a^***
	80ME	400	36.7 ± 0.2	35.1 ± 0.3	−1.6 ± 0.1^a^**,^b^	22.7 ± 0.6	24.4 ± 0.6	6.9 ± 1.0^a^***	77.8 ± 2.3	68.7 ± 2.37	−13.3 ± 1.3^a^***
	80ME	600	36.6 ± 0.2	35.2 ± 0.3	−1.0 ± 0.5^a^***	22.8 ± 0.3	24.7 ± 0.4	7.7 ± 1.0^a^***	76.5 ± 1.8	67.8 ± 2.17	−13.1 ± 2.7^a^***
	PC	25	36.5 ± 0.4	36.1 ± 0.4	−0.3 ± 0.1	25.5 ± 0.6	28.7 ± 0.3	10.8 ± 1.7	85.3 ± 0.8	78.6 ± 0.9	−7.5 ± 0.5
Solvent fractions	NC	–	36.0 ± 0.2	34.9 ± 0.2	−3.3 ± 0.1	25.3 ± 1.2	23.2 ± 0.9	−9.4 ± 2.3	81.4 ± 1.4	54.5 ± 3.7	−53.2 ± 12.3
	CF	100	37.1 ± 0.3	36.1 ± 0.3	−2.7 ± 0.1^a^,^b^,^c^*	25.0 ± 0.7	25.8 ± 0.7	3.0 ± 1.1^a^**,^b^	77.6 ± 1.8	64.5 ± 1.5	−20.4 ± 2.0^a^**
	CF	200	35.8 ± 0.3	35.0 ± 0.3	−2.3 ± 0.1 ^a^*,^b^*	28.0 ± 0.3	29.0 ± 0.5	3.5 ± 1.0^a^**,^b^	75.4 ± 1.4	63.0 ± 1.4	−19.8 ± 1.7^a^**
	CF	400	36.1 ± 0.3	35.4 ± 0.3	−1.9 ± 0.2^a^*,^b^*	26.7 ± 0.3	27.5 ± 0.2	4.1 ± 0.7^a^***	75.3 ± 1.7	64.5 ± 1.2	−16.9 ± 3.2^a^***
	PC	25	36.4 ± 0.3	36.2 ± 0.3	−0.5 ± 0.1	29.1 ± 0.7	32.3 ± 0.4	9.8 ± 2.1	75.2 ± 3.5	67.8 ± 3.0	−10.8 ± 1.6
	NC	–	36.0 ± 0.2	34.9 ± 0.2	−3.3 ± 0.1	25.3 ± 1.2	23.2 ± 0.9	−9.4 ± 2.3	81.4 ± 1.4	54.5 ± 3.7	−53.2 ± 12.3
	BF	100	35.9 ± 0.3	34.9 ± 0.3	−2.9 ± 0.3^a^*,^b^,^c^,^d^**	26.3 ± 0.3	26.9 ± 0.3	2.1 ± 0.3^a^*,^b^	81.7 ± 1.0	67.2 ± 2.5	−22.2 ± 3.5^a^**
	BF	200	36.0 ± 0.1	35.1 ± 0.1	−2.5 ± 0.6^a^*,^b^,^d^**	24.4 ± 0.7	24.9 ± 0.6	2.2 ± 0.4^a^*,^b^	80.5 ± 1.3	66.9 ± 2.8	−21.1 ± 3.7^a^**
	BF	400	35.7 ± 0.1	35.0 ± 0.1	−2.0 ± 0^a^*,^b^*	27.9 ± 1.3	28.7 ± 1.3	2.5 ± 0.1^a^*,^b^	78.6 ± 3.7	66.5 ± 2.8	−18.1 ± 1.4^a^**
	PC	25	35.9 ± 0.3	36.4 ± 0.3	−0.3 ± 0.1	29.3 ± 1.8	32.5 ± 1.5	10.1 ± 0.2	75.8 ± 3.7	68.8 ± 3.4	−10.2 ± 1.4
	NC	–	35.9 ± 0.2	34.7 ± 0.2	−3.6 ± 0.1	27.9 ± 1.3	23.6 ± 1.1	−18.2 ± 1.5	80.4 ± 2.5	54.6 ± 4.1	−50.8 ± 10.2
	AF	100	35.7 ± 0.4	34.6 ± 0.4	−3.4 ± 0^b^***	24.3 ± 1.5	24.7 ± 1.5	1.6 ± 0.3^a^*,^b^*	77.6 ± 1.8	56.3 ± 1.7	−38.0 ± 3.2^b^*
	AF	200	35.5 ± 0.4	34.3 ± 0.3	−3.3 ± 0^b^*	26.1 ± 1.3	26.6 ± 1.3	1.9 ± 0.4^a^*,^b^*	75.4 ± 1.4	55.7 ± 1.2	−35.6 ± 2.0^b^*
	AF	400	35.5 ± 0.3	34.4 ± 0.3	−3.3 ± 0^b^***	26.9 ± 1.4	27.5 ± 1.4	2.1 ± 0.9^a^*,^b^*	74.8 ± 3.6	57.2 ± 2.8	−31.1 ± 4.6^b^*
	PC	25	36.1 ± 0.2	35.9 ± 0.2	−0.5 ± 0.1	27.2 ± 1.4	30.5 ± 1.3	11.0 ± 0.8	75.2 ± 3.5	68.1 ± 3.2	−10.4 ± 1.8

Data are expressed as mean ± SEM; n = 6; NC: negative control; PC: positive control; AF: aqueous fraction; BF: butanol fraction; CF: chloroform fraction.

Compared to negative control.

Compared to positive control (chloroquine).

Compared to 200 mg/kg.

Compared to 600 mg/kg (80ME) 400 mg/kg (fractions).

p < 0.05; **p < 0.01; ***p < 0.001; D0, at day 0; D4, at day 4.