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. 2019 May 27;15:1744806919850383. doi: 10.1177/1744806919850383

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Overexpressing Npas4 or interfering with Npas4 changes response to postoperative mechanical stimuli in SPS rats. (a) rAAV-Npas4 vectors were injected seven days before SPS and increased Npas4 relieved SPS-induced postoperative hyperalgesia. *p < 0.05 versus control + rAAV-GFP group, ^#p < 0.05 versus control + rAAV-Npas4 group, ^&p < 0.05 versus SI + rAAV-GFP group. (b) Pretreatment with rAAV-Npas4 vectors aggravated SPS-induced postoperative hyperalgesia. *p < 0.05 versus control + Scram group, ^#p < 0.05 versus control + rAAV-Npas4 RNAi group, ^&p < 0.05 versus SI + Scram group. Statistical analyses were performed using two-way repeated measures ANOVA. SPS: single prolonged stress; Npas4: neuronal PAS domain protein 4; SI: SPS + incision; PWMT: paw withdrawal mechanical threshold; ANOVA: analysis of variance.