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. 2019 May 28;19:501. doi: 10.1186/s12885-019-5733-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effect of metabolic stress on cell proliferation in different cancer cell lines. KCL22 (Leukemia), KG1 (Leukemia), KU812 (Leukemia), SW480 (Colon cancer), SW620 (Colon cancer) and A549 (Lung Cancer) cells were cultivated under lipoprotein deficient medium (LPDS serum), low-serum (LS) medium (2% serum), hypoxia (Hyp, 2% O₂), or hypoxia in combination with LS medium (Hyp + LS). The number of live cells was counted using a trypan blue dye exclusion method, after 48 h of culturing. The dashed line indicates the initial seeding density of cells.*Significantly different (*p ≤ 0,05; **p ≤ 0,01; ***p ≤ 0,001), n.s not significant (p > 0,05)