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. 2019 May 28;19:505. doi: 10.1186/s12885-019-5731-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Clinical relevance of miR-188-5p expression in human GC tissue. a Immunohistochemical analysis of PTEN and β-catenin expression in serial sections of GC tumor specimens; 200×, 400×. b Percentage of specimens showing low or high miR-188-5p expression in relation to the expression levels of PTEN and nuclear β-catenin. ***, P < 0.001. c A linear regression analysis on the expression of PTEN versus miR-188-5p in the TCGA stomach cancer dataset. d Illustration of Wnt activation by miR-188-5p through suppression of PTEN. GC, gastric cancer; PTEN, phosphatase and tensin homolog