Table 2.
Association of AGRP, BDNF, FTO, GHRL and MC4R polymorphisms with obesity susceptibility
| Gene (polymorphism) | Control | Case | Model 1 | Model 2 | ||
|---|---|---|---|---|---|---|
| n=192 (%) | n=298 (%) | OR (95% CI) | P | OR (95% CI) | P | |
| AGRP (rs5030980)a | ||||||
| Genotype | ||||||
| CC | 179 (93.2) | 278 (93.3) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| CT | 13 (6.8) | 20 (6.7) | 1.08 (0.50–2.33) | 0.841 | 1.11 (0.47–2.59) | 0.811 |
| Allele | ||||||
| C | 371 (96.6) | 576 (96.6) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| T | 13 (3.4) | 20 (3.4) | 1.08 (0.50–2.33) | 0.841 | 1.11 (0.47–2.59) | 0.811 |
| BDNF (rs4074134) | ||||||
| Genotype | ||||||
| CC | 122 (63.6) | 204 (68.5) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| CT | 64 (33.3) | 82 (27.5) | 0.79 (0.51–1.22) | 0.293 | 0.87 (0.54–1.40) | 0.571 |
| TT | 6 (3.1) | 12 (4.0) | 1.42 (0.47–4.23) | 0.536 | 2.12 (0.60–7.50) | 0.242 |
| Dominant Model | ||||||
| CC | 122 (63.5) | 204 (68.5) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| CT+TT | 70 (36.5) | 94 (31.5) | 0.84 (0.55–1.28) | 0.419 | 0.95 (0.60–1.50) | 0.819 |
| Recessive Model | ||||||
| CC+CT | 186 (96.9) | 286 (96.0) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| TT | 6 (3.1) | 12 (4.0) | 1.53 (0.51–4.58) | 0.451 | 2.22 (0.63–7.77) | 0.212 |
| Allele | ||||||
| C | 308 (80.2) | 490 (82.2) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| T | 76 (19.8) | 106 (17.8) | 0.92 (0.65–1.32) | 0.663 | 0.92 (0.63–1.34) | 0.667 |
| FTO (rs9939609) | ||||||
| Genotype | ||||||
| TT | 71 (37.0) | 73 (24.5) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| TA | 85 (44.3) | 146 (49.0) | 1.66 (1.05–2.63) | 0.031 | 1.80 (1.09–2.98) | 0.021 |
| AA | 36 (18.7) | 79 (26.5) | 2.24 (1.28–3.92) | 0.005 | 2.24 (1.22–4.12) | 0.010 |
| Dominant Model | ||||||
| TT | 71 (37.0) | 73 (24.5) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| TA+AA | 121 (63.0) | 225 (75.5) | 1.82 (1.19–2.80) | 0.006 | 1.94 (1.21–3.09) | 0.006 |
| Recessive Model | ||||||
| TT+TA | 156 (81.2) | 219 (73.5) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| AA | 36 (18.7) | 79 (26.5) | 1.65 (1.01–2.69) | 0.044 | 1.58 (0.93–2.70) | 0.092 |
| Allele | ||||||
| T | 227 (59.1) | 292 (49.0) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| A | 157 (40.9) | 304 (51.0) | 1.53 (1.14–2.00) | 0.004 | 1.53 (1.13–2.07) | 0.006 |
| GHRL (rs696217) | ||||||
| Genotype | ||||||
| GG | 177 (92.2) | 277 (93.0) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| GT+TT | 15 (7.8) | 21 (7.0) | 0.76 (0.35–1.63) | 0.475 | 0.91 (0.38–2.18) | 0.838 |
| Allele | ||||||
| G | 369 (96.1) | 575 (96.5) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| T | 15 (3.9) | 21 (3.5) | 0.76 (0.35–1.63) | 0.475 | 0.91 (0.38–2.18) | 0.838 |
| MC4R (rs17782313) | ||||||
| Genotype | ||||||
| TT | 126 (65.6) | 172 (57.7) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| TC | 58 (30.2) | 113 (37.9) | 1.28 (0.84–1.96) | 0.254 | 1.39 (0.87–2.23) | 0.170 |
| CC | 8 (4.1) | 13 (4.4) | 1.20 (0.46–3.16) | 0.706 | 1.09 (0.38–3.10) | 0.872 |
| Dominant Model | ||||||
| TT | 126 (65.6) | 172 (57.7) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| TC+CC | 66 (34.4) | 126 (42.3) | 1.27 (0.84–1.19) | 0.249 | 1.35 (0.96–2.11) | 0.193 |
| Recessive Model | ||||||
| TT+TC | 184 (95.8) | 285 (95.6) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| CC | 8 (4.2) | 13 (4.4) | 1.10 (0.42–2.87) | 0.841 | 0.97 (0.35–2.74) | 0.962 |
| Allele | ||||||
| T | 310 (80.7) | 457 (76.7) | 1.00 (Ref.) | - | 1.00 (Ref.) | - |
| C | 74 (19.3) | 139 (23.3) | 1.20 (0.85–1.69) | 0.299 | 1.23 (0.84–1.80) | 0.284 |
Notes: P-value and OR were calculated using logistic regression and adjusted for gender and age (Model 1). P¥-value and OR were calculated using logistic regression and adjusted for age, gender, race/skin color, marital status and exercises habits (Model 2). aNo homozygous mutant was identified.
Abbreviations: AGRP, protein related to aguti; BDNF, brain-derived neurotrophic factor; CI, confidence interval; FTO, fat mass and obesity-associated gene; GHRL, ghrelin; MC4R, melanocortin 4 receptor; OR, Odds ratio; Ref, Reference.