Table S3.
Meta-analysis of the association between miR-423 rs6505162 and esophageal cancer risk
| miR-423 | N | A/C | CA/CC | AA/CC | AA+CA/CC | AA/CA+CC | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||
| 6 | 1.010(0.933–1.093) | 0.807 | 0.989(0.888–1.100) | 0.834 | 1.112(0.904–1.368) | 0.314 | 1.014(0.915–1.123) | 0.795 | 1.008(0.856–1.187) | 0.926 | |
| Ethnicity | |||||||||||
| Chinese Han | 2 | 1.035(0.934–1.146) | 0.512 | 0.989(0.873–1.121) | 0.863 | 1.223(0.911–1.642) | 0.181 | 1.013(0.898–1.142) | 0.834 | 1.228(0.917–1.645) | 0.169 |
| Chinese Kazakh | 1 | 0.908(0.704–1.172) | 0.460 | 0.959(0.666–1.382) | 0.824 | 0.746(0.402–1.383) | 0.352 | 0.921(0.648–1.308) | 0.645 | 0.763(0.426–1.367) | 0.364 |
| Indian | 1 | 1.009(0.804–1.267) | 0.937 | 0.985(0.678–1.429) | 0.935 | 1.021(0.657–1.588) | 0.927 | 0.997(0.705–1.409) | 0.984 | 1.030(0.704–1.509) | 0.878 |
| Caucasian | 1 | 1.464(1.102–1.945) | 0.009 | 1.185(0.814–1.724) | 0.376 | 3.121(1.442–6.752) | 0.004 | 1.378(0.962–1.974) | 0.080 | 2.894(1.362–6.150) | 0.006 |
| Black | 1 | 0.753(0.597–0.949) | 0.016 | 0.522(0.239–1.140) | 0.103 | 0.413(0.192–0.889) | 0.024 | 0.449(0.210–0.960) | 0.039 | 0.749(0.570–0.985) | 0.039 |
| Genotyping methods | |||||||||||
| PCR-LDR | 2 | 1.035(0.934–1.146) | 0.512 | 0.989(0.873–1.121) | 0.863 | 1.223(0.911–1.642) | 0.181 | 1.013(0.898–1.142) | 0.834 | 1.228(0.917–1.645) | 0.169 |
| PCR-RFLP | 2 | 1.169(0.980–1.395) | 0.083 | 1.079(0.829–1.406) | 0.571 | 1.399(0.965–2.030) | 0.077 | 1.165(0.908–1.495) | 0.229 | 1.319(0.946–1.837) | 0.102 |
| TaqMan | 1 | 0.753(0.597–0.949) | 0.016 | 0.522(0.239–1.140) | 0.103 | 0.413(0.192–0.889) | 0.024 | 0.449(0.210–0.960) | 0.039 | 0.749(0.570–0.985) | 0.039 |
| MALDI- TOF MS | 1 | 0.908(0.704-1.172) | 0.460 | 0.959(0.666–1.382) | 0.824 | 0.746(0.402–1.383) | 0.352 | 0.921(0.648–1.308) | 0.645 | 0.763(0.426–1.367) | 0.364 |
| Design | |||||||||||
| PB | 1 | 0.753(0.597–0.949) | 0.016 | 0.522(0.239–1.140) | 0.103 | 0.413(0.192–0.889) | 0.024 | 0.449(0.210–0.960) | 0.039 | 0.749(0.570–0.985) | 0.039 |
| HB | 5 | 1.049(0.965–1.140) | 0.264 | 1.001(0.898–1.115) | 0.987 | 1.204(0.970–1.493) | 0.092 | 1.029(0.928–1.141) | 0.585 | 1.188(0.969–1.458) | 0.098 |
Abbreviations: HB, hospital-based; PB, population-based; MALDI-TOF MS, Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry; PCR-LDR, Polymerase Chain Reaction ligase detection reaction; PCR-RFLP, Polymerase Chain Reaction restriction fragment length polymorphism.