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. 2018 Jul 28;1:51–61. doi: 10.1016/j.eclinm.2018.07.002

Table 2.

Clinical signs (associated or not) reported for allergic and non-allergic reactions and their respective diagnostic odds ratios to predict an allergic hypersensitivity mechanism. Signs are linked to allergic hypersensitivity where the lower limit of the 95% confidence interval (95% CI) of the diagnostic odds ratio exceeds 1.


Allergic
Non-allergic
Diagnostic odds ratio

N = 51
N = 152
[95% CI] for allergy to CM
Clinical signs N (%) N (%)
Cutaneous-mucous signs 44 (86.3%) 143 (94.1%) 0.35 [0.12, 1.02]
Digestive signs 12 (23.5%) 15 (9.9%) 2.81 [1.22, 6.5]
Respiratory signs 25 (49.0%) 48 (31.6%) 2.08 [1.09, 3.97]
Cardiovascular signs 33 (64.7%) 23 (15.1%) 10.28 [4.98, 21.24]
Only 1 category of signs 13 (25.5%) 96 (63.2%) 0.2 [0.1, 0.41]
2 categories of signs 16 (31.4%) 39 (25.7%) 1.32 [0.66, 2.64]
3 or 4 categories of signs 22 (43.1%) 17 (11.2%) 6.02 [2.85, 12.74]