Table 2.
Comparison of demographical and clinical characteristics between ICC patients with HBV infection and those without HBV infection.
| Variable | Patients without HBV infection (N = 157)a | Patients with HBV infection (N = 152)a | Pb |
|---|---|---|---|
| Gender | |||
| Female | 72 (45.9) | 27 (17.8) | < 0.001 |
| Male | 85 (54.1) | 125 (82.2) | |
| Age | |||
| Medium (IQR) | 61 (56–68) | 54 (47–61) | < 0.001 |
| ≤40 | 5 (3.2) | 8 (5.3) | |
| 40–60 | 65 (41.4) | 105 (69.1) | |
| >60 | 87 (55.4) | 39 (25.7) | |
| Cirrhosis (ultrasound) | |||
| No | 135 (91.2) | 78 (54.5) | < 0.001 |
| Yes | 13 (8.8) | 65 (45.5) | |
| Cirrhosis (pathology) | |||
| No | 143 (92.9) | 83 (54.6) | < 0.001 |
| Yes | 11 (7.1) | 69 (45.4) | |
| AFP (ng/mL) | |||
| Negative (<20) | 138 (89.6) | 98 (65.3) | < 0.001 |
| Positive (≥20) | 16 (10.4) | 52 (34.7) | |
| CA19-9 (U/mL) | |||
| Negative (<37) | 71 (46.4) | 77 (54.2) | 0.180 |
| Positive (≥37) | 82 (53.6) | 65 (45.8) | |
| HBeAg | |||
| Negative | 157 (100.0) | 107 (70.4) | < 0.001 |
| Positive | 0 (0.0) | 45 (29.6) | |
| HBcAb | |||
| Negative | 41 (26.1) | 0 (0.0) | < 0.001 |
| Positive | 116 (73.9) | 162 (100.0) | |
| Total bilirubin (μmol/L) | |||
| ≤20 | 140 (90.3) | 126 (84.6) | 0.129 |
| >20 | 15 (9.7) | 23 (15.4) | |
| Direct bilirubin (μmol/L) | |||
| ≤7 | 130 (83.9) | 118 (79.2) | 0.293 |
| >7 | 25 (16.1) | 31 (20.8) | |
| Albumin (g/L) | |||
| >35 | 148 (96.7) | 137 (97.2) | 1.000 |
| ≤35 | 5 (3.3) | 4 (2.8) | |
| NLR | |||
| ≤3.3 | 101 (64.3) | 100 (65.8) | 0.788 |
| >3.3 | 56 (35.7) | 52 (34.2) | |
| PLR | |||
| ≤117 | 65 (41.4) | 91 (59.9) | 0.001 |
| >117 | 92 (58.6) | 61 (40.1) | |
| Child–pugh score | |||
| A | 146 (95.4) | 141 (100.0) | 0.029 |
| B | 7 (4.6) | 0 | |
| BCLC stage | |||
| 0 | 1 (0.7) | 2 (1.3) | 0.573 |
| A | 35 (23.0) | 28 (18.8) | |
| B | 80 (52.6) | 82 (55.0) | |
| C | 36 (23.7) | 37 (24.8) | |
| Tumor diameter (cm) | |||
| <3 | 8 (5.3) | 16 (10.9) | 0.079 |
| ≥3 | 142 (94.7) | 131 (89.1) | |
| Tumor number | |||
| Single | 128 (85.3) | 119 (81.0) | 0.313 |
| Multiple | 22 (14.7) | 28 (19.0) | |
| Tumor encapsulation | |||
| No | 135 (90.0) | 120 (81.6) | 0.039 |
| Yes | 15 (10.0) | 27 (18.4) | |
| MVI | |||
| No | 134 (87.0) | 108 (73.0) | 0.002 |
| Yes | 20 (13.0) | 40 (27.0) | |
a
Data are presented as number (%), unless otherwise indicated. Some data do not sum up to the total number for the existence of missing data. Some percentages do not sum up to 100 because of rounding.
b
For age (continuous variable) and BCLC stage (rank variable), Mann–Whitney U test was conducted. For other variables (categorical variables), chi-square test was conducted.