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. Author manuscript; available in PMC: 2019 May 28.
Published in final edited form as: Ann Emerg Med. 2015 Jun 17;67(1):96–105.e5. doi: 10.1016/j.annemergmed.2015.04.036

Table E1.

Dose of study treatment per baseline international normalized ratio.

Baseline INR Dose of 4F-PCC,
IU of FIX/kg Body Weight* 		Plasma, mL/kg
Body Weight*
≥2-<4 25 10
≥4-≤6 35 12
>6 50 15

FIX, Factor IX.

*

The dose calculation was based on 100-kg body weight for patients weighing greater than 100 kg. 4F-PCC was administered at an infusion rate of less than or equal to 3 IU/kg per minute. The plasma infusion rate was at the discretion of the clinical team in both the acute bleeding and surgery studies; however, in the acute bleeding study, an infusion rate of 1 unit per 0.5-hour interval was recommended by the protocol.