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. 2019 May 21;10:555. doi: 10.3389/fphar.2019.00555

Figure 2.

Figure 2

ASIC1a modulates NMDA receptor-dependent LTD in young mice. (A) Normalized pooled data showing LTD in control condition (black) and in the presence of Pctx-1 applied before and during LFS (100 ng/ml, pink). Histogram represents the last 5 min of experiment in control (n = 12) condition or in the presence of PcTx-1 (30 ng/ml, mean ± SEM, n = 10, ***p < 0.001), (100 ng/ml, mean ± SEM, n = 10, ***p < 0.001). On top, representative traces are shown for each condition. (B) Normalized pooled data showing LTD in control condition (black) and in the presence of amiloride (100 μM, blue). Histogram represents the last 5 min of experiment in control condition (n = 12) or in presence of amiloride (n = 8) (mean ± SEM, ***p < 0.001). (C) Normalized pooled data showing LTD in control condition (black) and in the presence of PcTx-1 (100 ng/ml, pink) applied after LFS protocol. Histogram represents the last 5 min of experiment in control condition (n = 12) or in the presence of PcTx-1 (n = 6) (mean ± SEM, p > 0.05).