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. 2019 May 21;10:555. doi: 10.3389/fphar.2019.00555

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Copyright © 2019 Mango and Nisticò.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASIC1a modulates NMDA receptor-dependent LTD in adult mice. (A) Normalized pooled data showing LTD in control condition (black) and in the presence of Pctx-1 before and during LFS (100 ng/ml, pink). Histogram represents the last 5 min of experiment in control condition (n = 11) or in the presence of PcTx-1 (n = 9) (mean ± SEM, ***p < 0.001). On top, representative traces are shown for each condition. (B) Normalized pooled data showing LTD in control condition (black) and in the presence of amiloride (100 μM, blue). Histogram represents the last 5 min of experiment in control condition (n = 11) or in the presence of amiloride (n = 7) (mean ± SEM, ***p < 0.001). (C) Normalized pooled data showing LTD in control condition (black) and in the presence of PcTx-1 (100 ng/ml, pink) after LFS. Histogram represents the last 5 min of experiment in control condition (n = 11) or in the presence of PcTx-1 (n = 8) (mean ± SEM, p > 0.05).