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. 2019 May 21;10:555. doi: 10.3389/fphar.2019.00555

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Copyright © 2019 Mango and Nisticò.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PcTx-1 converts LTD of EPSC_NMDA to LTP. (A) Normalized pooled data showing LTD of EPSC_NMDA in control condition (black) and in the presence of PcTx-1 before and during LFS (100 ng/ml, pink). Histogram represents the last 5 min of experiment in control condition (n = 9) or in the presence of PcTx-1 (n = 7) (mean ± SEM, ***p < 0.001). On top, representative traces are shown for each condition. (B) Histogram represents the amplitude of ASIC1a-mediated inward current (control condition), in the presence of NMDA up to 10 min later, and in the presence of PcTx-1 (n = 6, mean ± SEM, ***p < 0.001). On the left, representative traces are shown for each condition.