Table 1.
Six-month cumulative incidences of mortality among patients with mPDAC.
| Characteristics | n | (%) | Event | (%) | Cause-specific mortality | Mortality from other causes | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| 6-month (%) | SE(10−5) | P | 6-month (%) | SE(10−5) | P | |||||
| Total | 10527 | 9187 | 60.3 | 2.4 | 5.9 | 0.54 | ||||
| Gender | 0.83 | 0.11 | ||||||||
| Male | 5680 | (54.0) | 4998 | (54.4) | 60.2 | 4.4 | 6.4 | 1.1 | ||
| Female | 4847 | (46.0) | 4189 | (45.6) | 60.3 | 5.3 | 5.3 | 1.1 | ||
| Age (years) | <0.001 | <0.001 | ||||||||
| Up to 55 | 1690 | (16.1) | 1420 | (15.5) | 49.1 | 15.7 | 4.5 | 2.7 | ||
| 56–65 | 3156 | (30.0) | 2716 | (29.6) | 56.1 | 8.2 | 5.1 | 1.6 | ||
| 66–75 | 3287 | (31.2) | 2835 | (30.9) | 60.2 | 7.8 | 5.7 | 1.7 | ||
| 76+ | 2394 | (22.7) | 2216 | (24.1) | 73.7 | 8.3 | 8.1 | 3.2 | ||
| Race/ethnicity | 0.33 | <0.001 | ||||||||
| White | 8283 | (78.7) | 7243 | (78.8) | 60.3 | 3.0 | 5.4 | 0.6 | ||
| Black | 1441 | (13.7) | 1258 | (13.7) | 60.7 | 17.5 | 8.3 | 5.4 | ||
| Others | 803 | (7.6) | 686 | (7.5) | 59.5 | 32.2 | 6.0 | 7.4 | ||
| Marital status | <0.001 | <0.001 | ||||||||
| Single | 1539 | (14.6) | 1338 | (14.6) | 61.7 | 16.3 | 7.9 | 4.9 | ||
| Married | 5887 | (55.9) | 5068 | (55.2) | 56.5 | 4.4 | 4.9 | 0.8 | ||
| Divorced | 1098 | (10.4) | 967 | (10.5) | 63.7 | 22.2 | 6.0 | 5.3 | ||
| Widowed | 1452 | (13.8) | 1339 | (14.6) | 71.2 | 14.6 | 6.9 | 4.5 | ||
| Others | 551 | (5.2) | 475 | (5.2) | 60.3 | 46.3 | 7.7 | 13.4 | ||
| Tumor location | 0.009 | 0.44 | ||||||||
| Body/tail | 4368 | (41.5) | 3814 | (41.5) | 61.1 | 5.8 | 5.8 | 1.3 | ||
| Head | 4194 | (39.8) | 3649 | (39.7) | 58.3 | 6.1 | 5.5 | 1.3 | ||
| Others | 1965 | (18.7) | 1724 | (18.8) | 62.6 | 12.5 | 6.9 | 3.3 | ||
| T stage, AJCC 7th | <0.001 | 0.1 | ||||||||
| T1 | 382 | (3.6) | 330 | (3.6) | 56.6 | 67.9 | 8.6 | 21.1 | ||
| T2 | 4036 | (38.3) | 3568 | (38.8) | 64.7 | 6.0 | 6.1 | 1.5 | ||
| T3 | 4865 | (46.2) | 3334 | (36.3) | 58.5 | 6.7 | 5.5 | 1.4 | ||
| T4 | 2244 | (21.3) | 1955 | (21.3) | 56.0 | 11.5 | 5.5 | 2.4 | ||
| N stage, AJCC 7th | 0.20 | 0.65 | ||||||||
| N0 | 6241 | (59.3) | 5464 | (59.5) | 61.0 | 4.0 | 5.9 | 0.9 | ||
| N1 | 4286 | (40.7) | 3723 | (40.5) | 59.2 | 6.0 | 5.8 | 1.3 | ||
| Tumor size (mm) | <0.001 | 0.9 | ||||||||
| ≤30 | 2559 | (24.3) | 2219 | (24.2) | 55.8 | 10.1 | 5.7 | 2.2 | ||
| 31–40 | 2731 | (25.9) | 2388 | (26.0) | 59.6 | 9.3 | 5.4 | 1.9 | ||
| 41–50 | 2209 | (21.0) | 1913 | (20.8) | 60.2 | 11.5 | 5.7 | 2.5 | ||
| 51–60 | 1388 | (13.2) | 1222 | (13.3) | 65.0 | 17.4 | 6.5 | 4.6 | ||
| >60 | 1640 | (15.6) | 1445 | (15.7) | 64.5 | 14.6 | 6.5 | 3.8 | ||
| Chemotherapy | <0.001 | <0.001 | ||||||||
| None/unknown | 4321 | (41.0) | 4050 | (44.1) | 81.3 | 3.5 | 9.9 | 2.1 | ||
| Yes | 6206 | (59.0) | 5137 | (55.9) | 45.9 | 4.3 | 3.1 | 0.5 | ||
| Radiation therapy | <0.001 | 0.2 | ||||||||
| None/unknown | 9953 | (94.5) | 8688 | (94.6) | 61.0 | 2.5 | 5.9 | 0.6 | ||
| Yes | 574 | (5.5) | 499 | (5.4) | 46.8 | 45.2 | 4.5 | 7.7 | ||
| Bone metastasis | 0.004 | 0.04 | ||||||||
| No | 9855 | (93.6) | 8574 | (93.3) | 59.9 | 2.6 | 5.7 | 0.6 | ||
| Yes | 672 | (6.4) | 613 | (6.7) | 65.9 | 34.7 | 7.9 | 11.1 | ||
| Brain metastasis | 0.015 | 0.45 | ||||||||
| No | 10472 | (99.5) | 9137 | (99.5) | 60.2 | 2.4 | 5.8 | 0.5 | ||
| Yes | 55 | (0.5) | 50 | (0.5) | 76.6 | 347.5 | 9.6 | 168.3 | ||
| Liver metastasis | <0.001 | 0.24 | ||||||||
| No | 2324 | (22.1) | 2001 | (21.8) | 49.3 | 11.3 | 5.7 | 2.4 | ||
| Yes | 8203 | (77.9) | 7186 | (78.2) | 63.4 | 3.0 | 5.9 | 0.7 | ||
| Lung metastasis | 0.009 | 0.27 | ||||||||
| No | 8400 | (79.8) | 7302 | (79.5) | 59.8 | 3.0 | 5.6 | 0.6 | ||
| Yes | 2127 | (20.2) | 1885 | (20.5) | 62.0 | 11.5 | 7.0 | 3.1 | ||
| Surgery | <0.001 | 0.3 | ||||||||
| No | 10313 | (98.0) | 9021 | (98.2) | 60.9 | 2.4 | 5.9 | 0.6 | ||
| Yes | 214 | (2.0) | 166 | (1.8) | 31.1 | 105.3 | 3.4 | 15.7 | ||
mPDAC – metastatic pancreatic duct adenocarcinoma; SE – standard error; AJCC – American Joint Committee on Cancer.