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. 2019 May 21;10:605. doi: 10.3389/fphys.2019.00605

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Copyright © 2019 Qing, Meng, Zhang, Yi, Zhang, Ariyadewa and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profile of escin/saline treatment in a swine decompression sickness (DCS) model. Sixteen swine were randomly divided into two groups (8 each) and were subjected to two simulated air dives in a hyperbaric chamber with an interval of 17 days. One week before each dive, the swine were administered daily with escin or saline for 7 days. Group 1 animals received escin treatment prior to the first dive and saline prior to the second; Group 2 received saline first and then escin. Assessment of DCS was performed for 3 days following each dive.