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. 2019 May 21;10:539. doi: 10.3389/fphar.2019.00539

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Copyright © 2019 Lu, Li, Huang, Cui, Zhang, Liu, Wang, Wang, Liu, Yuan and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene ontology (GO) analysis of affected genes upon perturbation of CRNG functions via siRNAs. (A) GO biological process distribution of differentially expressed genes. (B) GO molecular function distribution of differentially expressed genes. (C) GO cellular component distribution of differentially expressed genes. GO-based enrichment analysis showed that the differentially expressed genes mainly enriched in immune and inflammation related pathway.