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. 2019 May 21;10:539. doi: 10.3389/fphar.2019.00539

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Copyright © 2019 Lu, Li, Huang, Cui, Zhang, Liu, Wang, Wang, Liu, Yuan and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mRNA and miRNA expression of differentially expressed genes after CRNG interference and overexpression in PK-15 cells. β-actin and U6 were used as reference gene for mRNA and miRNA. It means that CRNG could increase kit ligand (KITLG), forkhead box protein 3 (FOXP3), IL-6, TNF-α mRNA and miRNA-451 expression and inhibit alanyl aminopeptidase (ANPEP), signal transducer and activator of transcription 5A (STAT5A), IL-2 and IL-10 mRNA expression. Blocking CRNG could increase ANPEP, STAT5A, IL-2 and IL-10 mRNA and miRNA-451 expression and inhibit KITLG, FOXP3, IL-6, TNF-α mRNA expression. All experiments were performed in biological triplicates with three technical replicates. ^∗p < 0.05, ^∗∗p < 0.01.