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. 2019 May 21;10:539. doi: 10.3389/fphar.2019.00539

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Copyright © 2019 Lu, Li, Huang, Cui, Zhang, Liu, Wang, Wang, Liu, Yuan and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Possible mechanisms of lncRNA regulating immunity and inflammation. Boosted lncRNA CRNG could increase FOXP3 and KITLG expression and inhibit ANPEP and STAT5A expression, thus promoting pro-inflammation cytokine and suppressing anti-inflammation cytokine and virus infection and production. Moreover, CRNG could enhance the expression of miR-451, thus protecting host from pathogens infection, and indirectly regulate the homeostatic of IL-6 levels. Each color line represents a signal pathway. ANPEP, Alanyl aminopeptidase, membrane; CRNG, Cyadox-related novel gene; FOXP3, Forkhead box protein 3; KITLG, Kit ligand; miR-451, microRNA 451, STAT5A: Signal transducer and activator of transcription 5A.